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Salivary Testosterone in Men: Diurnal Variation and Post-prandial Responses
The purpose is to evaluate Sal-T against standard biomarkers of male gonadal status based on serum T, calculated free T and BAT. The optimal salivary sampling in terms of fasting and time of day will also be defined. The ultimate aim is to add Sal-T into the Trust's repertoire of tests in investigating suspected hypogonadism in men.
To investigate whether salivary (free) testosterone is subject to similar prandial variations reported for serum total testosterone. Study 1: Assessment of diurnal variation in salivary testosterone adjusted for prandial state in 20 healthy men. Study 2: Measurement of salivary and serum testosterone and related biomarkers before and after a standard 75g oral glucose load in 40 men.
Age
20 - 60 years
Sex
MALE
Healthy Volunteers
Yes
The Royal Wolverhampton NHS Trust
Wolverhampton, West Midlands, United Kingdom
Start Date
October 30, 2020
Primary Completion Date
October 30, 2023
Completion Date
October 30, 2023
Last Updated
January 6, 2025
40
ACTUAL participants
Testosterone Measurements in healthy volunteers after fasting
OTHER
Testosterone Measurements after glucose loading
OTHER
Lead Sponsor
The Royal Wolverhampton Hospitals NHS Trust
NCT06689085
NCT06841328
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT03851627