Effects of Sitagliptin in Individuals With Genetically Decreased DPP4

Exclusion Criteria

• •The study will exclude volunteers with any significant medical conditions that may interfere with study participation, data interpretation, or pose safety risk(s) to the subject.
• •Recent hospitalization or acute illness such as infection within the past two weeks
• •Pregnancy
• •Use of insulin
• •Use of a GLP-1 agonist or DPP4 inhibitor medication
• •Use of oral diabetes agents other than metformin unless matched with controls
• •Type 1 diabetes
• •Chronic steroid use or use within the last 30 days
• •Significant liver disease including liver enzymes \>3 x upper limit of normal range
• •Renal dysfunction defined as eGFR\< 50mL/min/1.73m2
• •Significant cardiac disease such as heart transplantation
• •Significant gastrointestinal conditions that may interfere with drug absorption or GLP-1 release including bariatric surgery
• •Significant hematologic disease such as hematocrit \<35%
• •Use of chronic anticoagulation
• •Severe pulmonary disease
• •Severe neurologic or psychiatric disease
• •Inability to comprehend study procedures