Lenvatinib in Locally Advanced Invasive Thyroid Cancer

This is a multicenter, phase II, open-label study examining the effect of neoadjuvant lenvatinib being given to patients with extrathyroidal differentiated thyroid cancer (DTC) prior to surgery to remove cancerous tumors (thyroidectomy). \- The research study procedures include screening for eligibility and study treatment including evaluations and follow up visits. * This research study involves a study drug called lenvatinib. * It is anticipated that 30 people will participate in the study. The U.S. Food and Drug Administration (FDA) has not approved lenvatinib for the specific disease of extrathyroidal differentiated thyroid cancer (DTC) but it has been approved for other uses. Phase II clinical trials test the safety and effectiveness of an investigational drug to learn whether the drug works in treating a specific disease. "Investigational" means that the drug is being studied.