Bioequivalence Study for Fixed Dose Combination Zemimet® SR Tab. 50/1000 and Coadministration of Gemigliptin 50 mg and Metformin 1000 mg.

Exclusion Criteria

• •History serious hypersensitivity reactions
• •History or evidence of clinically significant diseases or any significant ongoing chronic medical illness
• •History or evidence of family diabetes
• •History or evidence of type 1 diabetes mellitus, diabetic ketoacidosis, diabetic pre-coma
• •History or evidence of shock or severe dehydrate or severe infection
• •History or evidence of preceding diarrhea or vomiting within 24 hours prior to admission in each period
• •History or evidence of drug addict or investigation with urine sample shows a positive test for drug of abuse
• •History of problems with swallowing tablet or capsule
• •History of sensitivity to heparin or heparin-induced thrombocytopenia
• •Any condition possibly affecting drug absorption
• •Have renal creatinine clearance (Clcr) \< 45 mL/min based on serum creatinine results at the screening laboratory test
• •12-lead ECG demonstrating QTc \>450 msec, a QRS interval \>120 msec or with an abnormality considered clinically significant at screening