Metabolomics Profiling Research of Human Cerebrospinal Fluid in Aging Process

Exclusion Criteria

• •1. patient refuses to sign informed consent
• •2. patients with coagulopathy, systemic infective disease and severe liver and renal function impairment
• •3. patients with spine or brain tumor and CNS disease
• •4. the presence of severe and/or uncontrolled and/or unstable medical disease within 12 months prior to study (e.g. acute pancreatitis, stroke, liver cirrhosis, congestive heart failure, and systemic immune disorder etc
• •5. Concurrent participation or planning to participate in another interventional clinical trial (Concurrent participation in an observational trial allowed)