Lead Sponsor

Xuanwu Hospital, Beijing

Age

30 - 75 years

Sex

ALL

Healthy Volunteers

No

•1. Patients with Multiple system atrophy diagnosed as "possible" or "probable" according to the 2008 MDS clinical diagnostic criteria;
•2. Age ≥30Aged ≤ 75years old;
•3. right handedness
•4. MMSE\>24
•5. the dosage and species of anti-parkinson drug is maintained during the treatment;
•6. The patient or his/her legal guardian agreed to participate in the trial and signed the informed consent.Ability to follow research plans and visit plans.
•7. FSS≥4

•1. Serious medical and mental illness;
•2. History of stroke, intracranial tumor and other central nervous system;
•3. Patients with suicidal tendencies and psychotic symptoms.
•4. MRI for contraindications, such as metal implants, claustrophobia, etc
•5. Contraindications for TMS (such as history of seizures, pregnant women, installation of pacemakers, metal inclusions in the body, intracranial hypertension, severe bleeding tendency, etc.)
•6. Patients who received TMS treatment for nearly half a year.