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Active Not RecruitingNCT04305366

MicroRNA Markers in Head and Neck Cancers

The purpose of this study is to investigate the presence of miRNA markers in saliva, blood, FNA and tissue specimens in patients with and without head and neck cancer and evaluate whether these miRNA ...

Lead sponsor: University of Colorado, Denver•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Colorado, Denver

Collaborators

National Cancer Institute (NCI)

Micro RNA (miRNA) markers were initially discovered in 1993 and recent research has shown that they have great potential for use as both surveillance and prognostic markers in cancer treatment, as well as potential targets for cancer therapy. Recent research has identified several miRNA markers which appear to be potential markers for head and neck squamous cell carcinoma, and these have been tested in both mouse and human banked tumor samples. These investigators hypothesize that these markers may also be present in other tissues, including fine needle aspiration biopsy, blood, and saliva specimens, and will be sensitive and specific to patients with known head and neck cancer.

Age

18 - 100 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Subjects between the ages of 18 and 100
•2. Patients who are seen and evaluated by a provider within the adult ENT clinic at University of Colorado Hospital
•3. Patients that present with a current or past diagnosis of head and neck cancer -OR-Patients undergoing tonsillectomy or sleep surgery as standard of care (control group)

Exclusion Criteria

•1. Under the age of 18 or over the age of 100
•2. Unwilling to participate

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 24, 2026Terms

Trial snapshot

StatusACTIVE_NOT_RECRUITING

Phase—

Enrollment225

Start dateNov 2012

Last updatedFeb 24, 2026

Condition

Squamous Cell Carcinoma of Head and Neck

Locations shown

University of Colorado Cancer Center

Aurora, Colorado

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 24, 2026Data synced to Clareo: May 17, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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