Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett's Esophagus

Exclusion Criteria

• •History of pre-existing esophageal stenosis/ stricture, esophageal diverticulum or significant esophageal anatomic abnormalities (masses, obstructive lesions, etc.)
• •History of head and neck malignancy or anatomical abnormalities of the nasopharynx
• •Any history of Ear, Nose and Throat (ENT) surgery
• •History of significant epistaxis or hereditary hemorrhagic telangiectasia (HHT)
• •Sinus or pulmonary infection in the last 4 weeks
• •Current use of blood thinners such as coumadin, warfarin, clopidogrel, heparin and/or low molecular weight heparin (requires discontinuation of medication 7 days prior to and 7 days after esophagogastroduodenoscopy \[EGD\] and Cytosponge administration, aspirin use is OK).
• •Known bleeding disorder
• •Pregnancy, or planned pregnancy during the course of the study.
• •Any history of esophageal varices, liver impairment of moderate or worse severity (Child's- Pugh class B \& C) or evidence of varices noted on any past endoscopy
• •Any history of esophageal surgery, except for uncomplicated fundoplication
• •History of coagulopathy, with international normalised ratio (INR) \>1.3 and/or platelet count of \<75,000
• •General poor health, multiple co-morbidities placing the patient at risk, or otherwise unsuitable for trial participation
• •Subject has any condition that, in the opinion of the investigator or sponsor, would interfere with accurate interpretation of the study objectives or preclude participation in the trial