Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)

Inclusion Criteria

• •be at least 18 years of age at Visit 1 of either gender and any race or ethnicity;
• •provide written informed consent and sign the HIPAA form;
• •be willing and able to follow all instructions and attend all study visits;
• •if on an active therapy for AKC prior to Visit 1, such treatment must have been maintained stably for at least 2 weeks for topical corticosteroids, topical and oral antihistamines, topical mast cell stabilizers, and topical tacrolimus and at least 3 months for topical and oral cyclosporine, and systemic corticosteroids. Such therapy must remain current throughout duration of study;
• •have a history of AKC or atopic dermatitis with a diagnosis of AKC at Visit 1 (by meeting inclusion 7 and 8);
• •be able to self-administer or receive subcutaneous injections satisfactorily or have a caregiver at home routinely available for this purpose. If unable to administer at home, patients must be willing to come in to office to receive injections that do not coincide with a visit;
• •present signs of active disease, defined as one or more of the following in at least one eye at Visit 2 (baseline):
• •1. \>/=2 score in conjunctival redness AND
• •2. \>/=2 score in at least one of the following lid disease signs: i. lid margin redness ii. lid excoriation
• •present symptoms of active disease, defined as having both of the following in at least one eye at Visit 2 (baseline):
• •1. \>/=2.5 score in ocular itching AND
• •2. \>/=2 score for ocular discomfort;
• •(for females capable of becoming pregnant) agree to have urine pregnancy testing performed at screening (must be negative) and at exit visit; must not be lactating; and must agree to use at least one medically acceptable form of birth control throughout the study duration and for at least 14 days prior to the first dose of investigational product (Visit 2) and for 1 month after the last dose of investigational product. Note: Women considered capable of becoming pregnant include all females who have experienced menarche and have not experienced menopause (as defined by amenorrhea for greater than 12 consecutive months) or have not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy);
• •have a calculated visual acuity of 0.7 logarithm of the minimum angle of resolution (logMAR) or better in at least one eye (Snellen equivalent of 20/100) and 1.0 logMAR (or count fingers) or better in the fellow eye (Snellen equivalent of 20/200) as measured using an Early Treatment for Diabetic Retinopathy Study (ETDRS) chart.