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TERMINATEDNANCT04294888

TMS in Preclinical and Prodromal AD: Modulation of Brain Networks and Memory

The purpose of this study is to assess the effects of non-invasive brain stimulation on memory in cognitively unimpaired older adults and in patients amnestic mild cognitive impairment (aMCI) due to A...

Lead sponsor: Massachusetts General Hospital•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Massachusetts General Hospital

Age

60 - 85 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Between the ages of 60-85
•2. All participants will be native English speakers
•3. Willing and able to consent to the protocol and undergo imaging and neuropsychological testing at the specified time points
•4. Participants with aMCI will be asked to bring a study partner to all visits
•5. Only patients with very mild or mild cognitive impairment (CDR 0.5 or CDR 1) will be included in the prodromal AD cohort

Exclusion Criteria

•1. History of head trauma involving loss of consciousness or alteration in consciousness
•2. Another major neurologic or psychiatric condition
•3. Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
•4. Any contraindication to MRI, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
•5. Longstanding premorbid history (i.e. longer than 10 years) of alcohol or substance abuse with continuous abuse up to and including the time that the symptoms leading to clinical presentation developed
•6. Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol.
•7. Unwilling to return for follow-up, undergo neuropsychological testing, TMS, and MR imaging

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 20, 2026Terms

Trial snapshot

StatusTERMINATED

PhaseNA

Enrollment4

Start dateMar 2020

Last updatedMar 20, 2026

Condition

Alzheimer Disease Mild Cognitive Impairment Aging

Locations shown

Massachuetts General Hospital

Charlestown, Massachusetts

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 20, 2026Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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