A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer

Exclusion Criteria

• •Has a known additional malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy, or in-situ cervical cancer, or other tumors that will not affect life expectancy
• •Impairment of gastrointestinal function or gastrointestinal disease that may signficantly alter the absorption of study drugs
• •History of or current evidence/risk of retinal verin occlusion or serous retinopathy
• •History of or current interstitial lung disease or non-infectious pneumonitis
• •Patients with a known history of testing positive for HIV
• •Clinically significant cardiac disease at screening
• •Any medical condition that would, in the investigator's judgment, prevent the patient's participation in the clinical study due to safety concerns or compliance with clinical study procedures.
• •Pregnant or lactating women
• •Other protocol-defined inclusion/exclusion may apply.