Comparison of Transdermal Fentanyl and Morphine for Oral Mucositis Pain in Nasopharyngeal Cancer Patients

Inclusion Criteria

• •Patients were pathologically newly diagnosed with nasopharyngeal carcinoma and had no previous history of other tumors
• •According to the treatment strategies of doctors, patients need to receive radiotherapy with or without chemotherapy (for example, neoadjuvant chemotherapy, concurrent chemotherapy, adjuvant chemotherapy) or targeted therapy
• •Never use a opioid before treatment
• •Hematology: WBC≥4.0×109/L, ANC≥1.5×109/L, PLT≥100×109/L,Hb≥90g/L.
• •Participants with the ability to assess the pain level
• •Willingness to return to enrolling institution for follow-up
• •Known allergy to fentanyl, morphine, or any known component of the drug formulation
• •Refuse to use of opioid drugs
• •Nasopharyngeal patients with mental illness
• •Current untreated or unresolved oral candidiasis or oral HSV infection
• •Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens
• •Pregnant or Nursing women
• •Men or women of childbearing potential who are unwilling to employ adequate contraception
• •Other contraindications or unsuitable conditions for radiotherapy