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Human Single Neuron Recordings in Epilepsy Patients | Clinical Trials | Clareo Health

UNKNOWNNA

Human Single Neuron Recordings in Epilepsy Patients

NCT04290416•University of Birmingham

Summary

This study uses single neuron recordings in pre-surgical epilepsy patients to uncover the neural mechanisms underlying memory formation and retrieval. A secondary aim is to improve diagnostic tools to identify epileptogenic tissue.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Interest in participation.
•Temporal lobe epilepsy that is clinically being investigated with implantations of depth electrodes as part of the pre-surgical epilepsy monitoring.
•Cognitive/language skills sufficient to follow experimental instruction and maintain focus on the experiment.

Exclusion Criteria

•Patient does not want to participate.
•Extra-temporal epilepsy, or electrode implantation strategy that does not allow the use of micro-macrowire electrodes.
•Cognitive/language skills insufficient to follow experimental instruction and maintain focus on the experiment.

Locations (1)

Queen Elizabeth UHB Hospital

Birmingham, West Midlands, United Kingdom

Key Dates

Start Date

February 4, 2016

Primary Completion Date

December 1, 2021

Completion Date

December 1, 2021

Last Updated

February 28, 2020

Enrollment

ESTIMATED participants

Conditions

EpilepsyMemory

Interventions

Microwire electrodes

DIAGNOSTIC_TEST

Thalamus Seizure Detection With a Deep Brain Stimulator System

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Epilepsy; Seizure

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RECRUITINGPHASE1

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

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Epilepsy

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RECRUITINGNA

Intracranial Investigation of Neural Circuity Underlying Human Mood

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 28, 2020Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Human Single Neuron Recordings in Epilepsy Patients

Inclusion Criteria

Exclusion Criteria

Thalamus Seizure Detection With a Deep Brain Stimulator System

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Intracranial Investigation of Neural Circuity Underlying Human Mood

Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment

AI-Based Mobile Intervention on Medication Non-Adherence and Transition

The Dynamics of Representational Change Underlying Recall