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Memory Retrieval and Encoding Investigated by Neural Stimulation | Clinical Trials | Clareo Health

ACTIVE_NOT_RECRUITINGNA

Memory Retrieval and Encoding Investigated by Neural Stimulation

NCT04286776•University of Pennsylvania

Summary

The purpose of this research is to understand biomarkers of human memory through correlational analyses and to use focal electrical stimulation as a causal manipulation to understand how biomarkers of memory relate to other brain states and behavioral measures.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Expected to undergo intracranial implantation and postoperative electroencephalographic monitoring as part of a standard clinical procedure for the treatment of pharmacologically resistant epilepsy
•2. Age 18 or older

Exclusion Criteria

•1. Any physical or cognitive disability or illness that would limit their ability to perform cognitive tasks
•2. Any medical condition that would, in the investigator's opinion, limit the subject's participation in the study.
•3. Unable or unwilling to provide informed consent
•4. MRI contraindications
•Standard clinical care includes a pregnancy test for female patients prior to the surgical implantation of the electrodes. Pregnant women are not surgically implanted.

Locations (11)

University of Colorado, Denver

Aurora, Colorado, United States

Emory University Hospital

Atlanta, Georgia, United States

National Institute of Neurological Disorders and Stroke

Bethesda, Maryland, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Mayo Clinic

Rochester, Minnesota, United States

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

Columbia University

New York, New York, United States

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

UT Southwestern Medical Center

Dallas, Texas, United States

Key Dates

Start Date

October 12, 2014

Primary Completion Date

December 31, 2024

Completion Date

December 31, 2024

Last Updated

November 5, 2024

Enrollment

800

ESTIMATED participants

Conditions

Epilepsy Intractable

Interventions

Direct electrical stimulation

DEVICE

Localizing Epileptic Networks Using MRI and iEEG

NCT04649008

EpilepsyEpilepsy Intractable+1 more

View study

RECRUITINGNA

Neural Mechanisms of Spatial Representations Beyond the Self

NCT05406349

Epilepsy Intractable

View study

COMPLETEDNA

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 5, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Memory Retrieval and Encoding Investigated by Neural Stimulation

Inclusion Criteria

Exclusion Criteria

Localizing Epileptic Networks Using MRI and iEEG

Neural Mechanisms of Spatial Representations Beyond the Self

Contribution of Genetics, Non-invasive Methods and Neuropsychology in Focal Cryptogenic Epilepsies

The Mosaic Brain: a New Diagnostic Approach in Focal Epilepsies

Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet

Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy