Pharmacologic Modulation of Hippocampal Activity in Psychosis

Exclusion Criteria

• •1. Age less than 18 or greater than 65.
• •2. Not communicative in English.
• •3. Unable to provide written informed consent.
• •4. Current medical or neurological illness.
• •5. History of severe head trauma.
• •6. BMI \< 17.5 or \> 45.
• •7. Meets criteria for diagnosis of substance or alcohol use disorder within the past month.
• •8. Positive urine pregnancy test at time of screening, before each testing day, or any potential concern for pregnancy at any time during the study.
• •9. Breastfeeding/nursing at time of screening or at any time during the study.
• •10. Conditions that preclude MR scanning
• •11. Conditions that preclude study drug administration
• •All of the above and in addition:
• •1. Current use of psychotropic or potentially psychoactive prescription medication.
• •2. Major psychiatric disorder as determined by DSM-V (major depression, bipolar disorder, obsessive compulsive disorder, post-traumatic stress disorder, etc)