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Investigation of Genetic Variations on Patients With Adverse Drug Events While on Direct Oral Anticoagulants (DOACs)
This retrospective study's objective is to evaluate if Cipherome's algorithm could have predicted the serious adverse drug reactions (ADRs) experienced by patients while on direct oral anti-coagulants (DOACs).
Using the latest next generation sequencing tools, this study will evaluate adverse drug reactions (ADRs) (e.g., major bleeding or treatment failure) in study participants while on direct oral anticoagulants (DOACs). A web-based program will analyze the data obtain from sequencing, and generate a drug safety score (DSS). The DSS risk score will be compared with pre-specified serious ADRs associated with DOAC therapy. A secondary analysis will involve discovery of novel variants that arise from our analysis and may potentially affect the outcome of DOAC treatment.
Age
18 - 99 years
Sex
ALL
Healthy Volunteers
Yes
Santa Clara Valley Medical Center
San Jose, California, United States
Start Date
January 10, 2020
Primary Completion Date
July 24, 2020
Completion Date
July 24, 2020
Last Updated
March 8, 2021
3
ACTUAL participants
Lead Sponsor
Cipherome, Inc.
Collaborators
NCT07169851
NCT06427317
Data Source & Attribution
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