A Study to Evaluate the Efficacy and Safety of Polatuzumab Vedotin in Combination With Bendamustine and Rituximab Compared With Bendamustine and Rituximab Alone in Chinese Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL).

Exclusion Criteria

• •History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies (MAbs) or recombinant antibody-related fusion proteins) or known sensitivity or allergy to murine products.
• •Contraindication to bendamustine or rituximab.
• •History of sensitivity to mannitol (mannitol is an excipient in bendamustine).
• •Prior use of any MAb, radioimmunoconjugate, or antibody-drug conjugate (ADC) within 5 half-lives or 4 weeks, whichever is longer, before Cycle 1, Day 1.
• •Treatment with radiotherapy, chemotherapy, immunotherapy, immunosuppressive therapy, or any investigational agent for the purposes of treating cancer within 2 weeks prior to Cycle 1, Day 1.
• •Ongoing corticosteroid use \> 30 mg/day prednisone or equivalent, for purposes other than lymphoma symptom control.
• •Completion of autologous SCT within 100 days prior to Cycle 1, Day 1.
• •Prior allogeneic Stem Cell Transplantation (SCT).
• •Prior treatment with Chimeric Antigen Receptor (CAR) T-cell therapy.
• •Eligibility for autologous SCT.
• •Grade 3b Follicular Lymphoma (FL).
• •History of transformation of indolent disease to DLBCL.
• •Primary or secondary CNS lymphoma.
• •Current Grade \> 1 peripheral neuropathy.
• •History of other malignancy that could affect compliance with the protocol or interpretation of results.
• •Evidence of significant, uncontrolled concomitant diseases that could affect compliance with the protocol or interpretation of results, including significant cardiovascular or pulmonary disease.
• •Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection (excluding fungal infections of nail beds) at study enrollment or any major episode of infection requiring treatment with IV antibiotics or hospitalization (relating to the completion of the course of antibiotics) within 4 weeks prior to Cycle 1, Day 1.
• •Participants with suspected or latent tuberculosis.
• •Positive Chronic Hepatitis B (HBV) infection or Hepatitis C (HCV) infection.
• •Known history of HIV infection.
• •Known infection human T-cell leukemia virus 1 virus.
• •Vaccination with a live vaccine within 28 days prior to treatment.
• •Recent major surgery (within 6 weeks before the start of Cycle 1, Day 1) other than for diagnosis.
• •Pregnant or breastfeeding or intending to become pregnant during the study or within 12 months after the final dose of study treatment.
• •Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or renders the patient at high risk from treatment complications.