A Study to Understand the Genetics and Clinical Course of Focal Segmental Glomerulosclerosis (FSGS), Treatment-Resistant Minimal Change Disease (TR-MCD), and Diabetic Nephropathy (DN)

Exclusion Criteria

• •For FSGS/TR-MCD patients:
• •1. Evidence of another kidney disease or kidney disease secondary to an infectious process.
• •2. History of human immunodeficiency virus (HIV), hepatitis B, or hepatitis C. Patients whose results are compatible with prior immunization or treatment may be included.
• •3. Body mass index (BMI) \> 42 kg/m2.
• •4. Significant history or evidence of clinically significant disorder, condition, current illness, or disease that, in the opinion of the Investigator, would pose a risk to patient safety or interfere with the study evaluation, procedures, or completion (eg, severe cardiac disease, cardiac conduction defect, or severe or chronic hepatobiliary disease).
• •5. History of malignancy not in remission within the last 5 years other than adequately treated basal cell or squamous cell skin cancer or cervical carcinoma in situ.
• •6. History of any organ or bone marrow transplant, including kidney grafts.
• •7. History of alcoholism or drug/chemical abuse within 12 months.
• •8. Preplanned surgery or procedures that would interfere with the conduct of the study.
• •For DN patients:
• •1. Evidence of another kidney disease or kidney disease secondary to an infectious process.
• •2. History of HIV, hepatitis B, or hepatitis C. Patients whose results are compatible with prior immunization or treatment may be included.
• •3. BMI \> 42 kg/m2.
• •4. Significant history or evidence of clinically significant disorder, condition, current illness, or disease that, in the opinion of the Investigator, would pose a risk to patient safety or interfere with the study evaluation, procedures, or completion (eg, severe cardiac disease, cardiac conduction defect, or severe or chronic hepatobiliary disease).
• •5. History of malignancy not in remission within the last 5 years other than adequately treated basal cell or squamous cell skin cancer or cervical carcinoma in situ.
• •6. History of any organ or bone marrow transplant, including kidney grafts.
• •7. History of alcoholism or drug/chemical abuse within 12 months.
• •8. Preplanned surgery or procedures that would interfere with the conduct of the study.
• •9. Renal disease that requires immunosuppressive therapy (currently, or in the past).