A Single Ascending Dose Trial of CVL-936 in Healthy Subjects

Exclusion Criteria

• •1. Subjects with a current history of significant pulmonary, gastrointestinal, renal, hepatic, metabolic, endocrine, hematological, immunological, psychiatric, or neurological disease that, in the opinion of the investigator or medical monitor, could compromise either subject safety or the results of the trial.
• •2. Subjects with epilepsy or a history of seizures
• •3. Systolic supine blood pressure ≥130 mmHg and/or supine diastolic blood pressure ≥80 mmHg at Screening or Day -1, or orthostatic hypotension at Screening or Day -1.
• •4. Subjects with a history of hypersensitivity to any dopamine-blocker medication.