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The Hemodynamic Effects of CGRP After Glibenclamide Administration in a Randomized Double-blind Cross-over Placebo-controlled Study With Healthy Volunteers
To investigate the hemodynamic effects of CGRP after glibenclamide administration.
20 healthy participants will randomly be allocated to receive CGRP infusion followed by glibenclamide or placebo on two different days. The aim of the study is to investigate the vascular effect of CGRP after glibenclamide administration. Repeated measurements covering the arteria radialis (RA), superficiel temporal artery (STA) and middle cerebral artery (MCA) before and after glibenclamide/placebo administration and CGRP infusion.
Age
18 - 60 years
Sex
ALL
Healthy Volunteers
Yes
Danish headache center
Glostrup Municipality, Copenhagen, Denmark
Mohammad Al-Mahdi Al-Karagholi
København S, Danmark, Denmark
Start Date
January 20, 2020
Primary Completion Date
August 1, 2020
Completion Date
September 1, 2020
Last Updated
September 9, 2020
20
ACTUAL participants
glibenclamide
DRUG
CGRP infusion
DRUG
Placebo
DRUG
Lead Sponsor
Danish Headache Center
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT07476053