Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National Cancer Centre, Singapore
With
Bristol-Myers Squibb
Age
21–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Signed written informed consent
* Subjects must have signed and dated and IRB-approved written consent form in accordance with regulatory and institutional guidelines. This must be obtained before the performance of any protocol-related procedures that are not part of normal subject care
* Subjects must be willing and able to comply with scheduled visits, treatment schedule, laboratory tests and other requirements of the study
Target population
* All subjects must have histologically confirmed extranodal natural-killer/T-cell lymphoma (NKTL)
* Subjects must have
* previously untreated stage III or IV NKTL, OR
* relapsed/refractory NKTL who has received at least 2 cycles of one prior regimen or previous radiotherapy administered with curative intent and one of the following:
* Failed to achieve at least a partial response
* Failed to achieve a complete response at the end of planned therapy with curative intent
* Progressed after initial response
* Age ≥ 21 years
* ECOG Performance status 0 - 2
* Subjects must have laboratory test results within these ranges:
* Absolute neutrophil count (ANC) ≥ 1.5 x10\^9/L
* Platelet count ≥ 75 x10\^9/L
* Creatinine clearance ≥ 40ml/min
* Total bilirubin ≤ 1.5 x upper limit of normal (ULN). Higher levels are acceptable if these can be attributed to active haemolysis or ineffective erythropoiesis
Women of childbearing potential (WOCBT) must agree to use dual methods of contraception and have a negative serum or urine pregnancy test prior study treatment. Male patients must use an effective barrier method of contraception if sexually active with a WOCBT
You may not be if
Previous treatment with an anti PD-1, anti PD-L1, anti PD-L2, anti-CD137, or anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways
Previous GDP therapy
Previous serious hypersensitivity reaction or symptomatic pancreatitis from L-asparaginase
Uncontrolled central nervous (CNS) disease
Uncontrolled hepatitis B or C
Known history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)
All toxicities attributed to prior anti-cancer therapy other than alopecia and fatigue must have resolved to grade 1 (NCI CTCAE version 4) or baseline before administration of study drug
Subjects with \> grade 1 peripheral neuropathy
Any serious or uncontrolled medical disorder, autoimmune disorder or active infection that, in the opinion of the investigator, may increase the risk associated with study participation, study drug administration or would impair the ability fo the subject to receive the study drug
Subjects who have had prior malignancies (other than NKTL) for ≤5 year with exception of currently treated basal cell, squamous cell carcinoma of the skin or carcinoma "in situ" of the cervix or breast.
Subjects who have had other anti-cancer therapy including radiation or experimental drug therapy within 28 days of enrollment
Subjects with known allergies or hypersensitivities to the study drugs
Prisoners or subjects who are involuntarily incarcerated
Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g., infectious disease) illness
Pregnant women or women who are breastfeeding are excluded from this study
Inclusion of women and minorities:
Men and women of all ethnic groups are eligible for this study
Clareo Health | Nivolumab in Combination With GDP/ L-asparaginase in NK/ T-cell Lymphoma
