Lead Sponsor

University of Chicago

Age

21 - No limit years

Sex

ALL

Healthy Volunteers

No

•age ≥ 21 years
•seen at University of Chicago Medical center with a planned PCI of a single CTO vessel
•must have either stable angina or angina equivalent
•must have a CTO with a clear donor vessel supplying most of the collaterals.

•subjects with a pacemaker or implantable cardioverter defibrillator
•contraindication to cardiac MRI, adenosine, heparin, or nitroglycerin
•cardiac transplantation
•Estimated glomerular filtration rate (eGFR) ≤ 30 mL/min/1.73m2, given the risk of contrast-induced nephropathy (CIN) and nephrogenic systemic fibrosis (NSF) associated with iodinated and gadolinium-based contrast agents, respectively, in patients with significant renal dysfunction
•Women who may potentially be pregnant will receive a pregnancy test and be excluded if pregnant
•Vulnerable populations such as children, college students, prisoners, non-English speakers, and those with diminished decision-making capacity
•Inability or refusal to consent for the study.