Repurposing Chlorpromazine in the Treatment of Glioblastoma

Inclusion Criteria

• •1. Newly diagnosed histologically-confirmed supra-tentorial GBM (World Health Organization grade IV) patients. Whenever feasible, patients will undergo maximal surgical resection or debulking, although patients with inoperable glioblastomas are also eligible.
• •2. Progression-free patients after having undergone maximal safe debulking surgery when feasible or biopsy, and
• •3. Patients undergone completed standard concomitant chemo-radiotherapy with temozolomide
• •4. Patients with provision of signed and dated, written informed consent prior to any study specific procedures, sampling and analyses.
• •5. Patients (both males and females) should employ adequate contraceptive measures which should be maintained during the whole duration of the trial
• •6. Additional eligibility criteria include: age between 18 and 70; Karnofsky Performance Status (KPS) score of 70 or higher; adequate kidney, liver, bone marrow, and cardiac function; total serum bilirubin level and liver- function values; isocitrate dehydrogenase 1/2 (IDH1/2) mutational status; MGMT methylation status assessment.