Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis

Inclusion Criteria

• •Definite IE, according to modified ESC 2015 criteria, caused by gram-positive cocci (staphylococci, streptococci and enterococci), including native, prosthetic valve IE and cardiac device-related IE.
• •18 years old or older.
• •Patients treated for at least 10 days of appropriate parenteral antibiotic therapy overall (according to guidelines and microbiology sensitivity testing), and at least 7 days of parenteral antibiotic therapy after valve surgery when indicated.
• •Absence of fever, microbiological or analytical findings suggesting persistent infection at randomization.
• •Absence of locally uncontrolled infection signs (abscess, pseudoaneurysm, fistula, enlarging vegetation) at randomization, confirmed by recent transesophageal echocardiography (performed within 48 h of randomization).
• •Women of childbearing potential who will agree to the use of effective contraceptive methods while on antibiotic treatment.