ZEBinix® Retention Rate in Epilepsy in Elderly Patients

Exclusion Criteria

• •1. History of ESL treatment
• •2. History of status epilepticus, seizures occurring in cluster, pseudo-seizures
• •3. History of severe hepatic impairment (aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \> 2 times ULN, gamma-glutamyltranspeptidase (GGT) \> 5 times ULN)
• •4. History of severe renal impairment (clearance CLCR \<30ml/min)
• •5. History of hypersensitivity to other carboxamide derivatives (e.g. carbamazepine, oxcarbazepine)
• •6. History of severe hyponatremia (\< 120 mmol/L)
• •7. Second or third degree atrioventricular block
• •8. More than one other antiepileptic drug