Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass

Exclusion Criteria

• •Inability to enroll the patient before the start of delivery in case of prenatal diagnosis, or 24 hours before surgery in case of postnatal diagnosis.
• •Doubt whether the aortic arch anomaly before birth requires cardiac surgery with CPB in the neonatal period.
• •Gestational age below 36 weeks and/or birth weight less than 2000 gram.
• •Surgery not requiring cardiopulmonary bypass.
• •Decision for "comfort care only".