Effect of Anti-inflammatory and Anti-microbial Co-supplementations in Traumatic ICU Patients at High Risk of Sepsis

Exclusion Criteria

• •• Patients admitted to ICU after time exceeding 24 hours from trauma onset.
• •* Patients whose age is less than 18 years.
• •* Pregnant female.
• •* Breast feeding women.
• •* Arrest within 24 hours of admission.
• •* Immune deficiency or administration of immune suppressant drugs.
• •* Serum calcium greater than or equal to 10 mg/dl or phosphate greater than or equal 6 mg/dl.
• •* History of primary parathyroid disease.
• •* Metabolic bone disease.
• •* Sarcoidosis.
• •* End stage renal disease.
• •* receiving intermittent renal replacement therapy (RRT).
• •* Failure of enteral feeding or any contraindication to enteral administration.
• •* Obesity , body mass index (BMI \> 35 kg/m2)
• •* Known contraindication to vitamin C or thiamine (oxalate nephropathy or known glucose-6-phosphate dehydrogenase deficiency)