National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
This study is to identify potential biomarkers for the early detection of Barrett's Esophagus, esophageal carcinoma (both adenocarcinoma and squamous cell carcinoma). Esophageal and gastric cytology will be collected via sponge capsule. Candidate genes will be tested with DNA isolated from these samples in order to identify optimal biomarkers to differentiate between Barrett's esophagus and esophageal/gastric cancer versus normal esophageal/gastric tissue.
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Undergoing esophagogastroduodenoscopy at Johns Hopkins Hospital from 1/2016 to 12/2025
Age greater than 18 years
Patients must be able to swallow a capsule
You may not be if
Patients in either arm with extra-esophageal malignancies including head and neck and gastric cancer
Patients who have undergone esophagectomy
Patients who have undergone radiation to the chest
Patients who are younger than 18
Patients with esophageal stents
Patients with esophageal strictures disabling passage of the capsule
