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Lead
Washington University School of Medicine
Both nonpharmacologic and pharmacologic interventions augment expression of EEG slow waves that mimic those of natural sleep. Closed loop auditory stimulation (CLAS) is a noninvasive inexpensive approach to augment the spectral power and duration of these slow waves. Whether in-phase CLAS may address this need is unknown, since acoustic potentiation of pharmacologically-induced slow waves has not been investigated. This prospective within-subject study of dexmedetomidine sedation paired with CLAS will assess the feasibility of augmenting EEG slow waves during sedation.
Age
18–40
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Age 18-40 years
Healthy volunteers (American Society of Anesthesiologists Physical Status 1-2).
You may not be if
Diagnosed sleep disorders
Habitually short sleepers
Diagnosed psychiatric disorders
Use of psychoactive medication (e.g., antidepressants, mood stabilizers or antipsychotics), diagnosed hearing disorder
Neck circumference \> 40 cm
Body Mass Index \> 30
Acknowledged recreational drug or nicotine use
Resting heart rate during slow wave sleep \< 40 beats per minute
