Effects of CKI for Oral Mucositis Caused by Radiotherapy for Head and Neck Cancer

Inclusion Criteria

• •1. Patients are pathologically diagnosed as stage III or stage Ⅳ squamous cell carcinoma of head and neck cancer (including nasopharyngeal carcinoma)and are in accordance with the diagnostic criteria of radiotherapy induced mucositis/ stomatitis;
• •2. Patients have no prior history of radiotherapy, and grade III oropharyngeal mucositis occured after the first radiotherapy;
• •3. Patients have no stomatological diseases such as ulcer, edema and exudation in the oropharyngeal mucosa before radiotherapy;
• •4. Eastern Cooperative Oncology Group (ECOG) performance Score is 0 or 1;
• •5. The function of each organ is basically normal, including: hemoglobins ≥ 9g/dL, platelets ≥ 80×10\^9/L, leukocytes ≥ 3×10\^9/L, liver function within 3 times the upper normal limit, creatinine clearance ≥ 60mL/min;
• •6. Patients aged between 18 and 75 years;
• •7. Patients have a life expectancy of at least 6 months;
• •8. Patients have fully understood the study and signed the informed consent voluntarily prior to any related procedures of the study.