Glucose Variability and Cognition in Prediabetes

Type 2 diabetes (T2DM) is now widely considered a major public health epidemic. T2DM is highly prevalent worldwide, is among the leading causes of death, and is an independent risk factor for dementia and less severe forms of cognitive dysfunction. The investigators are utilizing novel technology to understand the role of variability in glucose on neurocognition and Alzheimer's Disease (AD) risk among middle-aged and older adults at risk for diabetes. The central hypothesis is that even before diabetes onset, variability in glucose will be associated with worse cognitive function and higher AD risk. Participants will be asked to wear a glucose monitoring device over a 10-day period in their home environment. Assessment of neurocognitive function and AD risk biomarkers, in addition to sociodemographic factors, health habits and mood will also occur over two study visits.