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Exercise Training to Improve PTSD Symptoms and Health in Older Veterans | Clinical Trials | Clareo Health

COMPLETEDNA

Exercise Training to Improve PTSD Symptoms and Health in Older Veterans

Exploring the Effects of Exercise Training on PTSD Symptoms and Physical Health in Older Veterans With PTSD

NCT04199182•VA Office of Research and Development

Summary

Posttraumatic stress disorder (PTSD) is prevalent among military Veterans and is more than just a psychological condition; PTSD has profound negative impacts on health, function, and quality of life. Older Veterans are the largest patient population served by the Veterans Health Administration (VHA), and many have lived with PTSD for 40+ years. Veterans with PTSD engage in low levels of physical activity and spend much of their time in sedentary activities, adding to their risk of physical disability. The benefits of exercise on mental health and physical well-being in older adults are well-substantiated, but the effects of exercise training on late-life PTSD symptoms is a new area of study. This study is designed to examine the effects of 6 months of supervised exercise training on PTSD symptoms and PTSD-related conditions (e.g., functional impairment, sleep) in 188 older Veterans with PTSD.

Eligibility

Age

65 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Veteran status
•registered for care at Durham VA Health Care System (VAHCS)
•live within 50 miles of fitness facility
•meet diagnostic criteria for PTSD as assessed by the CAPS-5

Exclusion Criteria

•history of any psychiatric disorder with severe psychotic features in the past 5 years (e.g., bipolar disorder, mania), as indicated by ICD-10 codes F20-F29 (ICD-9 category 298.9)
•prominent suicidal ideation or hospitalization for suicidality in the previous 6 months
•clinically significant: neurological disorder, systemic illness affecting central nervous system (CNS) function, or history of seizure disorder in the past 5 years
•uncontrolled diabetes defined as:
•* Abnormal fasting plasma glucose 126 mg/dL, random plasma glucose 200 mg/dL
•* no active medications for diabetes management (Metformin, insulin, etc.)
•* no clinical notes in the patient's electronic health record (EHR) indicating monitoring by primary care physician (PCP) or Endo for diabetes management)
•* end stage liver disease or currently receiving dialysis
•* physical disabilities precluding use of exercise equipment (assistive mobility devices acceptable)
•* significant cognitive impairment or diagnosis of Alzheimer's Disease or Dementia
+1 more criteria

Locations (1)

Durham VA Medical Center, Durham, NC

Durham, North Carolina, United States

Key Dates

Start Date

June 7, 2021

Primary Completion Date

February 10, 2025

Completion Date

February 28, 2025

Last Updated

October 24, 2025

Enrollment

ACTUAL participants

Conditions

Post-traumatic Stress Disorder

Interventions

Exercise Training

BEHAVIORAL

Healthy Aging Attention Control (HA-ATC)

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 24, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Exercise Training to Improve PTSD Symptoms and Health in Older Veterans

Inclusion Criteria

Exclusion Criteria

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