Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes

Exclusion Criteria

• •Non-diabetic kidney disease as indicated by medical history and/or laboratory findings
• •Renal failure (eGFR\<15 ml/min/1.73m2), dialysis or kidney transplantation
• •Treatment with beta-blocking medication
• •Uncontrolled arrhythmia, 2. or 3. degree AV-block or sick sinus syndrome - assessed from a standard 12-lead electrocardiogram
• •Pregnancy or breastfeeding (urine HCG is performed on all fertile women)
• •Systolic blood pressure \< 90 or \> 200 mmHg
• •Patients who, in the judgement of the investigator, is incapable of participating
• •* Claustrophobia
• •* Known heart disease
• •* Known lung disease
• •* Have had surgery the past six weeks
• •* Have foreign bodies of metal in the body (e.g. pacemaker, metal plates, metal screws)
• •* Absent pulse
• •* Raynauds syndrome
• •* Buergers Disease (thromboangiitis obliterans)
• •* Inadequate or interrupted circulation
• •* Anticoagulation treatment
• •* Coagulopathies (hypo or hyper coagulable states)
• •* Arterial atherosclerosis
• •* Insufficient collateral perfusion
• •* Partial or full thickness burns over the cannulation site
• •* Synthetic arterial or vascular grafts or infection at the proposed site of cannulation Patients with type 1 diabetes will have the possibility to participate in the study without getting arterial blood gas sampling.