Cambridge University Hospitals NHS Foundation Trust
With
The European Association for the Study of the Liver
Children's Liver Disease Foundation
Age
0–18
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis made under 18 years of age.
Diagnosis of NAFLD spectrum disease (simple steatosis (NAFL), steatosis with abnormal transaminases, NASH ± fibrosis or cirrhosis)
Diagnosis established by:
* Radiological evidence of hepatic steatosis (e.g. increased hepatic echogenicity on ultrasound), with
* Exclusion of secondary causes (negative serological liver screen for HBV/HCV, caeruloplasmin \>0.20g/L, no history of excess alcohol consumption, no evidence of iron overload, and no clinically significant alpha-1 antitrypsin (A1AT) phenotype (i.e. SZ, ZZ, SS), with or without
* Histology (\>5% steatosis and histology consistent with paediatric NAFLD)
You may not be if
Secondary fatty liver disease (e.g. glycogen storage diseases, Wilson disease, viral hepatitis, drug-related, autoimmune hepatitis, type 1 diabetes mellitus)
