8\) liver and kidney function: serum creatinine ≤ 1.5 times the upper limit of normal value; AST and alt ≤ 2.5 times the upper limit of normal value; total bilirubin ≤ 1.5 times the upper limit of normal value, or patients with Gilbert's syndrome ≤ 2.5 times the upper limit of normal value;
9\) patients have good compliance with the planned treatment, can understand the research process of this study and sign the written informed consent
You may not be if
1\) previously received cytotoxic chemotherapy, endocrine therapy, biological therapy or radiotherapy for any reason;
2\) patients with stage IV metastasis at the initial diagnosis;
2\) New York Heart Association (NYHA) rating of patients with heart disease above grade II (including grade II);
3\) patients with serious systemic infection or other serious diseases;
4\) patients who are known to be allergic or intolerant to chemotherapy drugs or their adjuvants;
5\) in the past 5 years, there have been other malignant tumors, except the cured carcinoma in situ of cervix and skin cancer without melanoma;
6\) pregnancy or lactation, as well as childbearing age patients who refuse to take appropriate contraceptive measures during the trial;
7\) participated in other experimental studies within 30 days before the administration of the first study drug;
8\) patients not suitable for the study were judged by the researchers.
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