Safety of Lower Scalp Cooling Temperature to Prevent Hair Loss From Chemotherapy in Breast Cancer Patients

Exclusion Criteria

• •Any other concurrent malignancy including hematological malignancies (i.e. leukemia or lymphoma)
• •Baseline alopecia (defined CTCAE v5.0 grade \> 1)
• •Subjects who are scheduled for bone marrow ablation chemotherapy
• •Male gender
• •Age \>/= 75 years
• •Personal history of migraines, cluster or tension headaches as defined as actual medical diagnosis by a physician and/or prescribed medications. If personal history of migraines was related to a past medical problem that is now resolved, subject may go on study at the discretion of the Principal Investigator.
• •Subjects who have had prior chemotherapy
• •Subjects who have had \>/=1 previous chemotherapy exposure resulting in alopecia
• •An existing history of scalp metastases or suspected presence of scalp metastasis
• •Subjects with cold sensitivity, cryoglobulinemia, cryofibrinogenemia, or cold migraine pot-traumatic cold dystrophy
• •Previously received, or scheduled to undergo skull irradiation