Letizia Castelli, MD, PhD

CONTACT

Shalom Haggiag, MD

CONTACT

Lead Sponsor

San Camillo Hospital, Rome

Collaborators

Age

18 - 55 years

Sex

ALL

Healthy Volunteers

No

•age between 18 and 55 years (inclusive);
•cognitive impairment, defined as failure in the SDMT, defined as a corrected score less than 38, i.e. below the 5th percentile of normative value;
•Expanded Disability Status Scale (EDSS) score between 2.0 and 5.5;
•ability to stand upright for at least 180 seconds without any support;
•ability to understand and comply with study requirements;
•ability to provide a valid informed consent before any study procedure.

•relapse in the previous 6 months;
•initiation of disease-modifying or symptomatic treatments or physiotherapy programme in the 3 months prior to study entry;
•any medication/physiotherapy changes occurring over the previous 3 months;
•significant visual impairment, defined as a Visual System scoring more than 2 at the Kurtzke Functional Systems Score;
•clinically relevant depression, defined as Beck Depression Inventory-II (BDI-II) score equal or more than 14;
•overt dementia, defined as an adjusted Mini Mental State Examination (MMSE) score equal or less than 24;
•history of epilepsy or seizures;
•any medical condition, including musculoskeletal disorders that can interfere with the study conduction.