About Pricing FAQs Providers Trials Blog

Login Get started

Finding studies

Your health journey, clearly organized.

Questions? feedback@clareohealth.com

Product

How it works
Pricing
For Providers
Trials

Company

About
Blog
FAQ

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Clareo Health | GDNF Gene Therapy for Parkinson's Disease

GDNF Gene Therapy for Parkinson's Disease

NCT04167540·3 sites·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

Lead

Brain Neurotherapy Bio, Inc.

With

AskBio Inc
California Institute for Regenerative Medicine (CIRM)

Age

35–75

Sex

ALL

Healthy volunteers

Not accepted

You may be eligible if

Male and female adults 35-75 years of age (inclusive)
Diagnosed with Parkinson's disease
Modified Hoehn and Yahr stage I-III OFF medication
Time since receiving a clinical diagnosis of PD and disease severity consistent with one of the following:
1. EITHER: Less than 5 years since clinical diagnosis of PD and mild to moderate UPDRS III OFF score
2. OR: At least 4 years since clinical diagnosis of PD and moderate to severe UPDRS III OFF score
Responsiveness to levodopa

You may not be if

Atypical parkinsonism
Severe dyskinesia
Presence of dementia, psychosis, substance abuse or qualify as "severe depression"
Prior brain surgery (i.e. deep brain stimulator or DBS implantation) or other brain imaging abnormalities
Receiving an investigational drug
History of cancer or poorly controlled medical conditions that would increase surgical risk
Inability to tolerate laying flat in an MRI or allergy to gadolinium

The record

StatusActive not recruiting

PhasePhase 1

Taking part11

StartedApr 2020

UpdatedSep 19, 2025

Conditions

Parkinson's Disease

Where3

University of California Irvine
Irvine, California, United States
University of California San Francisco
San Francisco, California, United States
The Ohio State University Medical Center
Columbus, Ohio, United States