2. Strongly suspected or documented COPD, defined by the presence of the following criterias:
* Persistent respiratory symptoms (dyspnoea, chronic cough or sputum)
* History of exposure to a risk factor such as tobacco smoke
* If available, pulmonary function tests showing airflow limitation not fully reversible (post-bronchodilator ratio of FEV1/ FVC ratio \< 0.7)
3. ACRF, defined by the presence of the two following criteria:
* COPD exacerbation defined by a change in the patient baseline respiratory symptoms at least 24 hours and requiring a change in regular respiratory medication
* Acute respiratory failure \<24h (polypnea ≥ 30 breaths.min-1 or use of accessory respiratory muscles) requiring ventilatory support, either invasive (implemented because of respiratory distress) or NIV (implemented because of hypercapnic acidosis with PaCO2 ≥ 45 mmHg and pH ≤ 7.35).
4. Admission to an ICU, a step-up unit or a respiratory care unit
5. Inform consent from the patient or his surrogates. In patients who are not able to consent on admission an emergency inclusion procedure will be allowed, with a mandatory delayed consent.
6. Affiliation to (or benefit from) French health insurance system
You may not be if
Previous diagnostic of asthma, according to "GINA" international guidelines (40)
Recent use of systemic corticosteroids, defined by systemic corticosteroids use in the past 7 days
Contra-indication of systemic corticosteroids treatment: allergy to corticosteroids, uncontrolled severe arterial hypertension, uncontrolled diabetes mellitus, gastro-intestinal ulcer bleeding
Pneumothorax at randomization
Extracorporeal life support (ECMO or ECCO2R) at inclusion
Moribund patient life expectancy \< 3 months
Pregnancy
Patients protected by law
Exclusion period due to other interventional clinical trial enrolment which can influence primary outcome
Previous inclusion in the present study
Clareo Health | Comparison of Corticosteroids vs Placebo on Duration of Ventilatory Support During Severe Acute Exacerbations of COPD Patients in the ICU
