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Neurobiological Effects of Oxytocin in Schizophrenia - Imaging Study | Clinical Trials | Clareo Health

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Neurobiological Effects of Oxytocin in Schizophrenia - Imaging Study

Neurobiological Effects of Oxytocin on Metacognitive Deficits in Schizophrenia: A Pharmacological - Imaging Genetics Study

NCT04158167•National Institute of Mental Health and Neuro Sciences, India

View on ClinicalTrials.gov

Summary

To investigate whether 24IU oxytocin can result in changes in functional brain connectivity in patients with schizophrenia and healthy individuals using functional magnetic resonance imaging (fMRI). The study will also examine the effect of oxytocin receptor gene polymorphism on the functional connectivity

Eligibility

Age

18 - 50 years

Sex

MALE

Healthy Volunteers

Yes

Inclusion Criteria

•1. General impairment in intellectual functioning
•2. History of alcohol or substance dependence in the last 12 months (with the exception of nicotine)
•3. Contraindication to oxytocin like hypersensitivity, vascular disease, chronic nephritis, epilepsy, asthma
•4. Past history of head injury resulting in loss of consciousness or neurosurgery
•5. Concomitant severe medical conditions
•6. Metal implants or paramagnetic objects within the body or claustrophobia which may interfere with the MRI.
•Healthy volunteers:
•1. Males between 18 and 50 years

Exclusion Criteria

•Schizophrenia subjects:
•1\) Life-time diagnosis of psychiatric illnesses including substance abuse 2) General impairment in intellectual functioning 3) Past history of head injury resulting in loss of consciousness or neurosurgery 4) Concomitant severe medical or neurological conditions 5) Metal implants or paramagnetic objects or claustrophobia 6) Family history of schizophrenia, schizoaffective or schizophreniform disorder in family member (sibling, parent or offspring) 7) Contraindication to oxytocin like hypersensitivity, vascular disease, chronic nephritis, epilepsy, asthma.

Locations (1)

National Institute of Mental Health and Neurosciences

Bangalore, Karnataka, India

Key Dates

Start Date

September 1, 2013

Primary Completion Date

December 30, 2018

Completion Date

December 30, 2018

Last Updated

November 8, 2019

Enrollment

ACTUAL participants

Conditions

Schizophrenia

Interventions

oxytocin

DRUG

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Psychotic DisordersSchizophrenia Spectrum Disorders

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RECRUITING

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 8, 2019Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Neurobiological Effects of Oxytocin in Schizophrenia - Imaging Study

Inclusion Criteria

Exclusion Criteria

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