Dose Reduced Dasatinib (70 mg Daily) as First-line Treatment for Newly Diagnosed CML-CP

Exclusion Criteria

• •History of any TKI treatments.
• •History of Pulmonary arterial hypertension and Pleural effusion
• •NYHA cardiac class 3-4 heart disease.
• •Uncontrolled angina within 12 months.
• •Diagnosed or suspected congenital long QT syndrome.
• •Any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or torsades de pointes).
• •Prolonged QTc interval on pre-entry electrocardiogram (\>450 msec).
• •Patients with active uncontrolled psychiatric disorders including: psychosis, major depression, and bipolar disorders.
• •Women of pregnancy potential must practice an effective method of birth control, unless otherwise instructed, during the course of the study in a manner such that risk of failure is minimized.
• •Pregnant or breast-feeding women are excluded.