National Institute of Neurological Disorders and Stroke (NINDS)
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Undergoing one of the following procedures at Jackson Memorial Hospital:
* Clipping of an unruptured cerebral artery aneurysm
* Endovascular treatment of unruptured cerebral aneurysms (including those receiving coiling)
2. ≥ 18 years of age
3. Willing and able to give informed consent
You may not be if
1\) Subjects meeting any of the following criteria will be excluded:
Dissecting, traumatic, or mycotic brain aneurysm.
Women who are pregnant, or have a positive urine or blood (β-hCG) pregnancy test.
Women who are breastfeeding.
Any clinically significant psychiatric or psychological disease, which would preclude the patient from completing the protocol.
Patients with known Human Immunodeficiency Virus (HIV) infection or other known immunodeficiency.
Patient with renal or liver failure
Interstitial pneumonitis
History of lymphoma
History of skin cancer
Hypersensitivity to sirolimus
Severe or unstable concomitant condition disease or chronic condition, which in the opinion of the investigator could affect assessment of the safety or efficacy of study intervention.
Clareo Health | Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms
