Evaluation of Duloxetine and Innovative Pelvic Floor Muscle Training in Women With Stress Urinary Incontinence

Exclusion Criteria

• •Recent use of any pharmacologic agent used to treat symptoms of urinary incontinence in the past six months
• •History of anti-incontinence surgery in the past 12 months
• •Use of onabotulinumtoxinA for the treatment of urinary incontinence in the past 12 months
• •History of pelvic prolapse repair or urethral surgery in the past 12 months
• •History of pelvic floor muscle training in the past 12 months
• •History of interstitial cystitis or bladder-related pain
• •Chronic severe constipation
• •Clinically significant renal or hepatic impairment
• •Clinically significant heart impairment
• •Pregnant woman, lactating, or actively trying to become pregnant
• •Non-compliance with limitation of duloxetine treatment for mixed urinary incontinence
• •Positive urinary tract infection
• •Use of rehabilitation aids (pessary, urethral plugs, vaginal beads, etc.)
• •Use of antidepressant therapy
• •Insufficient understanding of pelvic floor exercises and/or omitting exercises
• •Participation in any clinical study in the past six months