Efficacy and Tolerability of Venoactive Drugs in Patients With Chronic Venous Diseases C4a&b in Real Clinical Practice.

Exclusion Criteria

• •Chronic venous disease of СЕАР class C0-С3 or class С4-С6
• •History of alcohol or drug abuse or use of narcotic drugs
• •Peripheral artery disease
• •Lymphatic edema of the lower extremities
• •Secondary varicose veins, angiodysplasia, or neoplasia
• •Arterial disease (ankle-brachial index \<0.9)
• •Infection within the past 6 weeks
• •Any of the following concomitant diseases, which can affect the results:
• •Connective tissue disease (including rheumatoid arthritis), arthritis
• •Heart failure
• •Chronic kidney disease
• •Decompensated diabetes mellitus
• •Skin diseases of non-venous origin
• •Intermittent claudication (peripheral artery disease)
• •Diseases of the bones or joints of the lower extremities
• •Malignancy
• •Treatment with drugs potentially causing leg edema (calcium channel blockers, hormonal drugs, NSAIDs, etc.) History of deep vein thrombosis (within the past year) History of superficial thrombophlebitis (within the past 3 months) History of surgical intervention (within the past 3 months) Patient cannot walk (regardless of the cause) Predictable poor adherence to treatment Participation of a patient in the intervention study within the previous 3 months For women: pregnancy or breastfeeding, the desire to become pregnant within at least 2 months after the study Patients with a contraindication to diosmin-containing agents, including Detralex Patient uses the topical treatments contraindicated in case of skin integrity violation.