Effect of Tai Chi as Treatment for IBS-C

You may be eligible if

• Inclusion
• 1. Age 18 - 70 years
• 2. BMI ≤ 35
• 3. Rome IV criteria for IBS-C
• 4. Continued IBS-C throughout run-in period
• 5. Compliant with reporting during run-in
• 6. Ability to follow verbal and written instructions
• 7. Ability to record daily patient reported outcomes via RedCap survey
• 8. Ability to use the GeoPain app on a smart phone
• 9. Ability to use Zoom as a platform for conducting study visits virtually
• 10. Ability to respond to 80% of the daily diaries
• 11. Ability to attend at least 7 out of 8 Tai Chi classes
• 12. Informed consent form signed by the subjects
• Exclusion
• 1. Unwilling to abstain from participation in Tai Chi (other than that provided for the study) or other mind-body practices (i.e. yoga that is new to regimen) until completion of the study
• 2. Non-English speaking
• 3. Participation in any other clinical trial with active intervention within the last 30 days
• 4. Non-compliance with reporting during run-in period
• 5. Inability to stand without assistance for 20 minutes
• 6. Patients reporting any usage of a prohibited medication during the run-in period
• 7. History of regular opiate or narcotic pain-reliever use
• 8. Current use of prescribed or illicit opioids
• 9. Change in current medication regimen related to GI motility, laxatives, or antidepressants
• 10. Abdominal pain severity of 4 on a 0-4 visual analogue scale, where 4 is the worst possible pain, during pre-screen or run-in
• 11. Severe osteoarthritis
• 12. Severe rheumatoid arthritis
• 13. Severe constipation defined as \<1 bowel movement per week without use of laxatives
• 14. History of GI lumen surgery (including gastric bypass) at any time or other GI or abdominal operations within 60 days prior to entry into the study
• 15. History of small bowel resection (except if related to appendectomy)
• 16. Subjects anticipating surgical intervention during the study
• 17. Angina, coronary bypass, or myocardial infarction within 6 months prior to Screening Visit
• 18. Crohn's disease or ulcerative colitis
• 19. History of intestinal stricture (e.g., Crohn's disease)
• 20. BMI \>35
• 21. Pregnancy (or positive urine pregnancy test(s) in females of childbearing potential)
• 22. Known history of diabetes (type 1 or 2)
• 23. History of gastroparesis
• 24. History of abdominal radiation treatment
• 25. History of pancreatitis
• 26. History of malabsorption or celiac disease
• 27. History of intestinal obstruction or subjects at high risk of intestinal obstruction including suspected small bowel adhesions
• 28. History of human immunodeficiency virus
• 29. History of cancer within the past 5 years (except adequately-treated localized basal cell skin cancer or in situ uterine cervical cancer)
• 30. Neurological disorders, metabolic disorders, or other significant disease that would impair their ability to participate in the study
• 31. Any other clinically significant disease interfering with the assessments according to the Investigator (e.g., disease requiring corrective treatment, potentially leading to study discontinuation)
• 32. Any relevant biochemical abnormality interfering with the assessments according to the Investigator
• 33. Inability to attend at least 7 out of the 8 Tai Chi classes
• 34. Inability to respond to 80% of the daily diaries