Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Tufts Medical Center
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Group 1 (Hypertonic saline non-responders):
At least 18 years of age
Ability to consent
Diagnosis of Dry Eye Disease (DED) based on:
* Symptoms of DED, shown with SANDE score of 50mm or greater
* Two or more of the following objective signs in the same eye: 1. Schirmer test of 10 mm or less over 5 minutes; 2. Fluorescein tear break-up time (FTBUT) of 7 seconds or less; 3. Meibomian gland expression (MGE) grade of 2 or greater for at least 3 out of 5 glands
HS response result of one of the following:
* Reduction of discomfort/pain rating
* No change of discomfort/pain rating
* Increase in discomfort/pain rating score of 1 step or less
Group 2 (Hypertonic saline non-responders):
At least 18 years of age
Ability to consent
Diagnosis of DED based on:
* Symptoms of DED, shown with SANDE score 50mm or greater
* Two or more of the following objective signs in the same eye: 1. Schirmer test of 10 mm or less over 5 minutes; 2. Fluorescein tear break-up time (FTBUT) of 7 seconds or less; 3. Meibomian gland expression (MGE) grade of 2 or greater for at least 3 out of 5 glands
HS response result of an increase in discomfort/pain rating of greater than 1 step
You may not be if
Presence of centralized pain as indicated by a proparacaine challenge test (PCT) of less than 50% ocular surface discomfort reduction
Unable to speak English
History of ocular surgery, corneal infection, or corneal injury within the last 3 months
Active ocular allergies or other condition that could impact the study results
Allergic to benzalkonium chloride "BAK" (an eye-drop preservative)
Changes in topical or systemic medications in the last 3 months or anticipated changes in medication during the course of treatment
Use of other topical treatments
Concurrent enrollment in other studies that in the opinion of the investigator will interfere with the results of this study
