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DNA Repair Activity in the Skin of Day and Night Shift Workers | Clinical Trials | Clareo Health

RECRUITINGNA

DNA Repair Activity in the Skin of Day and Night Shift Workers

Pilot Study on DNA Repair Activity in the Skin of Day and Night Shift Workers

NCT04122456•Wright State University

Summary

The purpose of this study is to test how the skin of night shift workers responds to artificial sunlight (ultraviolet B radiation; UVB) at two different times of the day in comparison to normal day shift workers. After the skin biopsies are obtained, they will be brought to the laboratory to be exposed to UVB radiation and to measure UVB responses.

Eligibility

Age

18 - 40 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Male/Female
•Fair skin (Fitzpatrick types I and II)
•Age 18 to 40
•Able to comprehend procedures/risks
•Primarily work and are awake during normal daylight hours (6 am to 6 pm), or primarily work and are awake during night shifts hours (between the hours of 6 pm and 6 am) or may work a mixture of these shifts over the past 3 months. Rotating shifts will be categorized based on the majority of hours worked on average during the last 3 months. Able to fill out a 3-month calendar of work schedule.

Exclusion Criteria

•Known photosensitivity
•Currently on photosensitizing medications
•Diabetes Mellitus
•On any hormonal agents (e.g., birth control pills)
•History of abnormal scarring
•History of skin infections
•History of skin cancers
•History of sleep disorders such as sleep apnea or insomnia
•Known allergy to lidocaine local anesthetic
•Pregnancy or nursing
+1 more criteria

Locations (1)

Wright State Physicians

Fairborn, Ohio, United States

Key Dates

Start Date

December 7, 2022

Primary Completion Date

December 1, 2025

Completion Date

December 1, 2025

Last Updated

February 6, 2025

Enrollment

ESTIMATED participants

Conditions

Skin Cancer

Interventions

Ultraviolet B Radiation

RADIATION

No Ultraviolet B Radiation

OTHER

Contacts

Manager, Clinical Research Operations

CONTACT

937-245-7500 pturesearch@wrightstatephysicians.org

Regulatory Specialist

CONTACT

937-245-7500 pturesearch@wrightstatephysicians.org

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 6, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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DNA Repair Activity in the Skin of Day and Night Shift Workers

Inclusion Criteria

Exclusion Criteria

Pilot Trial of Supplemental Vitamin A and Nicotinamide

Prospective Collection of Clinical Data and Human Body Material (HBM) of Cutaneous Melanoma and Non Melanoma Patients. Biobank Huidkanker

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