Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

Exclusion Criteria

• •1. weight \< 3 kilograms
• •2. cyanotic congenital heart disease (other than Patent Foramen Ovale (PFO) or Patent Ductus Arteriosus (PDA))
• •3. tracheostomy at time of screening
• •4. invasively ventilated for \> 7 days when meet ARDS criteria above
• •5. cardiac failure as predominant cause of respiratory failure
• •6. primary obstructive airway disease (asthma, bronchiolitis) by judgement of clinician as the primary cause of respiratory failure
• •7. alternative known chronic lung disease as cause of respiratory failure (cystic fibrosis, eosinophilic pneumonia, interstitial pneumonitis, pulmonary hemosiderosis, cryptogenic organizing pneumonia)
• •8. severe neurologic morbidity not expected to survive \> 72 hours
• •9. any limitations of care at time of screening
• •10. previous enrollment in this study