Analysis of the Microbiome in Rosacea

Exclusion Criteria

• •Subjects unable to provide informed consent.
• •Subjects with significant medical history or concurrent illness that the investigator feels are not safe for study participation.
• •Recently treated (4 weeks for topical antibiotics/steroids/other anti- inflammatory medications on the face, 8 weeks for systemic antibiotics/steroids/other immunosuppressive agents) or current (skin) diseases that would affect clinical evaluation and skin sampling.
• •Subjects with a history of facial surgeries and cosmetic procedures (i.e. laser therapy, resurfacing, dermal fillers, and deep chemical peels) within 6 months.
• •Subjects with facial features (i.e. significant hair growth) that would affect clinical evaluation and skin sampling.
• •Participants with a history of chronic gastrointestinal disease, diabetes mellitus, cardiac disease or immunodeficiency disease.
• •Intake of proton pump inhibitors, H2 receptor antagonists, laxatives, or antidiarrheal medication, NSAIDs, or antacids within 2 weeks prior to enrollment.
• •Participants with a history of major surgery of the GI tract (5 years).
• •Participants with a known hypersensitivity to tetracyclines or doxycycline or topical ivermectin
• •Subjects unwilling to avoid facial washing for 24 hours prior to sampling and to come to sampling visit without make-up.
• •Subjects with known allergy to lidocaine and epinephrine.
• •Subjects with known bleeding disorders.
• •Subjects with a history of keloids or excessive scarring.
• •Pregnant subjects. Self-reporting will be used to determine whether a patient is pregnant