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Impaired olfaction is one of the major complaints of patients with nasosinus polyposis, with nasal obstruction. In case of failure of medical treatment for patients with polyposis nasosinusal, they may use endoscopic surgery nasosinusal. Before surgery, 73% are hyposmic or anosmic, compared to 43% after surgery. Persistence of hyposmia or anosmia despite the removal of polyps can be explained by mechanisms inflammatory in the mucous membrane of the olfactory cleft. In addition, studies in mice have shown a degeneration of primary olfactory neurons at the level of the olfactory mucosa in connection with directly with TNF alpha, a pro-inflammatory molecule.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Chu Saint-Etienne
Saint-Etienne, France
Start Date
February 5, 2020
Primary Completion Date
July 6, 2021
Completion Date
July 29, 2021
Last Updated
October 25, 2022
3
ACTUAL participants
Sniffin Stick Test
DIAGNOSTIC_TEST
numerical evaluation scale for olfaction
OTHER
numerical evaluation scale for nasal obstruction
OTHER
nasal outcome test
OTHER
dosage of 17 cytokines
BIOLOGICAL
Lead Sponsor
Centre Hospitalier Universitaire de Saint Etienne
NCT06914908
NCT05246267
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT07125586